物质信息
ID:180863
名称和标识
别名
3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedioneDL-Aminoglutethimide
IUPAC传统名
aminoglutethimide
IUPAC标准名
3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
化合物性质
理化性质
溶解度
methanol: soluble
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble1.2 mg/mL
H2O: slightly soluble0.2 mg/mL
acetonitrile: soluble
0.1 M HCl: soluble
熔点
152-154 °C(lit.)
外观
white
安全信息
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明
P261-P305+P351+P338
危险公开号
36/37/38
德国WGK号
3
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
RTECS编号
MA4026950
GHS警示词
Warning
GHS危险声明
H315-H319-H335
安全公开号
26-36
欧盟危险性物质标志
刺激性 (Xi)药理学性质
相关基因信息
human ... CYP17A1(1586), CYP19A1(1588)rat ... Cyp19a1(25147)
描述信息
Biochem/physiol Actions
DL-Aminoglutethimide is a derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. It also blocks the peripheral conversion (aromatization) of androgenic precursors to estrogens. The D-isomer is 30 times more potent at inhibiting aromatase activity, whereas the L-isomer is more potent at inhibiting cholesterol side-chain cleavage (steroidogenesis).
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A9657.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
DL-Aminoglutethimide is a derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. It also blocks the peripheral conversion (aromatization) of androgenic precursors to estrogens. The D-isomer is 30 times more potent at inhibiting aromatase activity, whereas the L-isomer is more potent at inhibiting cholesterol side-chain cleavage (steroidogenesis).
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A9657.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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