物质信息
ID:180746
名称和标识
IUPAC传统名
decitabine
IUPAC标准名
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
别名
decitabine4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one2′-Deoxy-5-azacytidine5-Aza-2′-deoxycytidine
化合物性质
产品相关信息
纯度
≥97%
安全信息
RTECS编号
XZ3012000
GHS危险声明
H302-H315-H319-H335-H341-H360
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
安全公开号
26-36/37
欧盟危险性物质标志
有毒 (T)GHS警示性声明
P201-P261-P281-P305+P351+P338-P308+P313
危险公开号
61-22-36/37/38-68
GHS警示词
Danger
德国WGK号
3
理化性质
溶解度
acetic acid: water (1:1): soluble50 mg/mL
描述信息
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
General description
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
Live Chat and Frequently Asked Questions are available for this Product.
General description
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
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