物质信息
ID:180742
名称和标识
IUPAC传统名
chamomile
IUPAC标准名
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
别名
4′,5,7-TrihydroxyflavoneApigenin
化合物性质
安全信息
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
危险公开号
36/37/38
GHS警示性声明
P261-P305+P351+P338
RTECS编号
LK9276000
GHS警示词
Warning
保存温度
-20°C
安全公开号
26-36
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
德国WGK号
3
GHS危险声明
H315-H319-H335
欧盟危险性物质标志
刺激性 (Xi)药理学性质
相关基因信息
human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)mouse ... Hexa(15211)rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)
产品相关信息
纯度
≥97% (TLC)
生物来源
from parsley
理化性质
溶解度
DMSO: soluble27 mg/mL
1 M KOH: soluble50 mg/mL
外观
yellow powder
熔点
>300 °C(lit.)
描述信息
Biochem/physiol Actions
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.
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