物质信息
ID:179261
名称和标识
别名
1,2-Dioctanoyl-sn-glycerol1,2-Dicapryloyl-sn-glycerol(S)-Glycerol 1,2-dioctanoateD-α,β-DicaprylinDOG
IUPAC标准名
(2S)-1-hydroxy-3-(octanoyloxy)propan-2-yl octanoate
IUPAC传统名
(2S)-1-hydroxy-3-(octanoyloxy)propan-2-yl octanoate
化合物性质
产品相关信息
运输包装
dry ice
纯度
≥96% (TLC)
理化性质
外观
yellow oil
溶解度
DMSO: soluble
安全信息
德国WGK号
3
RTECS编号
RH0764500
保存温度
-20°C
个人保护装置
Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
描述信息
Caution
Some isomerization to the 1,3-isomer may occur in storage or in solution.
Other Notes
Synthetic 1,2-diglyceride of short chain fatty acid.
Biochem/physiol Actions
Cell-permeable, diacylglycerol (DAG) analog, and activator of protein kinase C (PKC). Shown to possess a lower affinity for the α isoform of PKC than for the other isoforms. Mimics the action of tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA). Inhibits slow (L-type) Ca2+ current in rat heart cells independently of PKC activation and also inhibits the cGMP-gated channel in rod outer segments by a phosphorylation-independent mechanism.
Some isomerization to the 1,3-isomer may occur in storage or in solution.
Other Notes
Synthetic 1,2-diglyceride of short chain fatty acid.
Biochem/physiol Actions
Cell-permeable, diacylglycerol (DAG) analog, and activator of protein kinase C (PKC). Shown to possess a lower affinity for the α isoform of PKC than for the other isoforms. Mimics the action of tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA). Inhibits slow (L-type) Ca2+ current in rat heart cells independently of PKC activation and also inhibits the cGMP-gated channel in rod outer segments by a phosphorylation-independent mechanism.
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