Application
The all-D maganin peptides were resistant to enzymatic degradation and caused equivalent amounts of electrical conductivity when tested in planar lipid bilayers. The D enantiomers were equally active against representative Gram-negative and Gram-positive species.
Biochem/physiol Actions
Antibiotic peptide. Thought to preferentially bind to anionic phospholipids abundant in bacterial membranes with the formation of dynamic peptide-lipid supramolecular pore and cell permeabilization, magainins are positively charged and amphiphatic. Binding to artificial neutral membranes has also been demonstrated.