60% Urinary (metabolites, <10% unchanged drug)

Class A (UK)

Schedule II (US)

TD, IM, IV, oral, sublingual, buccal

(IV)= 2.5 minutes
Intranasal = 6.5 mins
Transdermal = 7 hours (range 3–12 h)

80-85%

hepatic, primarily by CYP3A4

C (US)

92% (transdermal)
89% (intranasal)
50% (buccal)
33% (ingestion)

Moderate - High

87.5°C (189.5°F)