物质信息
ID:1450
名称和标识
IUPAC标准名
5-amino-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol
别名
8-Azaguanine
IUPAC传统名
@8-azaguanine
数据登录号
CAS号
化合物性质
理化性质
溶解度
Insoluble
疏水性(logP)
-0.71 [HANSCH,C ET AL. (1995)]
描述信息
Drug Groups
experimental
Description
One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids. [PubChem]
References
•
Tong, George L.; Lee, William W.; Goodman, Leon; Frederiksen, Sune (1965). "Synthesis of some 2′-deoxyribosides of 8-azaadenine". Archives of Biochemistry and Biophysics (University of California: Elsevier) 112 (1): 76. "http://dx.doi.org/10.1016/0003-9861(65)90012-3":http://dx.doi.org/10.1016/0003-9861(65)90012-3
•
Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS: Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31.
[Pubmed]
External Links
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参考文献
• Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS: Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31. Pubmed
• Tong, George L.; Lee, William W.; Goodman, Leon; Frederiksen, Sune (1965). "Synthesis of some 2′-deoxyribosides of 8-azaadenine". Archives of Biochemistry and Biophysics (University of California: Elsevier) 112 (1): 76. "http://dx.doi.org/10.1016/0003-9861(65)90012-3":http://dx.doi.org/10.1016/0003-9861(65)90012-3