物质信息
ID:1390
名称和标识
商标名
CoactabsSelexid
IUPAC标准名
[(5R,6R)-6-[(E)-(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbonyloxy]methyl 2,2-dimethylpropanoate
别名
Amdinocillin pivoxilPivmecillinamum [inn-latin]Pivmecilinamo [inn-spanish]Pivmecillinam
IUPAC传统名
[(5R,6R)-6-[(E)-(azepan-1-ylmethylidene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbonyloxy]methyl 2,2-dimethylpropanoate
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CAS号
化合物性质
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描述信息
Drug Groups
approved
Description
Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin. [PubChem]
Indication
Used to treat infections due to mecillinam-sensitive organisms such as urinary tract infections, salmonellosis and typhoid fever.
Pharmacology
Pivmecillinam is a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption
Well absorbed following oral administration.
References
•
Sjovall J, Huitfeldt B, Magni L, Nord CE: Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84.
[Pubmed]
•
Graninger W: Pivmecillinam--therapy of choice for lower urinary tract infection. Int J Antimicrob Agents. 2003 Oct;22 Suppl 2:73-8.
[Pubmed]
•
Pivmecillinam (selexid). Drug Ther Bull. 1978 Dec 22;16(26):103-4.
[Pubmed]
分子图谱
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参考文献
• Pivmecillinam (selexid). Drug Ther Bull. 1978 Dec 22;16(26):103-4. Pubmed
• Sjovall J, Huitfeldt B, Magni L, Nord CE: Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84. Pubmed
• Graninger W: Pivmecillinam--therapy of choice for lower urinary tract infection. Int J Antimicrob Agents. 2003 Oct;22 Suppl 2:73-8. Pubmed