物质信息
ID:1381
名称和标识
商标名
CalsaminBenzalinCersonEpinelbonEunoctinGersonSonebon tofraniln aSonnolinPacisynRadedormRelactSandoz nitrazepamSomnibelSomniteHipsalIbrovekIpersedMogadonNelbonNeuchlonicCalsminEpibenzalinHipnaxNitrazepam-10PaxisynRemnosSonebonSuremTrazeninInsominMegadonNelmatNeozepamNitradosNitrazadonAtempolDormicumDormo-purenDumolidEunoktinImesontApo-nitrazepam tablets BPApodormMogadoneNitrempaxNoctesedSomnasedUnisomniaDormin-5EatanEatan nMitidinNitrenpaxPelsonPersopitSomitranAlodormImesonLA 1 (VAN)MagadonMogadanNitravetNitrazepam-5
别名
1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-oneNitrazepam2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-oneNitrazepamum [inn-latin]NTZ1, 3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-oneN-desmethylnimetazepam
IUPAC传统名
nitrazepam
IUPAC标准名
7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
化合物性质
理化性质
疏水性(logP)
2.25 [HANSCH,C ET AL. (1995)]
描述信息
Drug Groups
approved
Description
A benzodiazepine derivative used as an anticonvulsant and hypnotic.
Indication
Used to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening.
Pharmacology
Nitrazepam is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative, anxiolytic, amnestic, anticonvulsant, and skeletal muscle relaxant properties. Nitrazepam shortens the time required to fall asleep and lengthens the duration of sleep. It is also useful for the management of myoclonic seizures.
Toxicity
Nitrazepam is a drug which is very frequently involved in drug intoxication, including overdose. Nitrazepam overdose may result in stereotypical symptoms of benzodiazepine overdose including intoxication, impaired balance, slurred speech. In cases of severe overdose this may progress to a comatose state with the possibility of death.
Affected Organisms
Humans and other mammals
Absorption
Bioavailability is 53-94% following oral administration.
Half Life
15-38 hours (mean elimination half life 26 hours).
References
•
Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41.
[Pubmed]
•
Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6.
[Pubmed]
•
Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72.
[Pubmed]
•
Podhorna J, Krsiak M: Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice. Behav Pharmacol. 2000 Apr;11(2):143-51.
[Pubmed]
•
Nowakowska E, Chodera A: Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats. Pharmacol Biochem Behav. 1991 Feb;38(2):265-6.
[Pubmed]
External Links
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参考文献
• Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. Pubmed
• Podhorna J, Krsiak M: Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice. Behav Pharmacol. 2000 Apr;11(2):143-51. Pubmed
• Nowakowska E, Chodera A: Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats. Pharmacol Biochem Behav. 1991 Feb;38(2):265-6. Pubmed
• Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. Pubmed
• Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. Pubmed