物质信息
ID:1347
名称和标识
别名
1-(4-Chlorophenyl)-2-methyl-2-propanamineChlorphentermine1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochlorideChlorphenteramineChlorphentermine hydrochlorideChlorphenterminum hydrochlorideP-chlorphentermine hydrochloridealpha,alpha-dimethyl-p-chlorophenethylamine4-Chloro-alpha,alpha-dimethylphenethylamineChlorophentermineChlorpentermineBeta-(p-chlorophenyl)-alpha,alpha-dimethylethylamineChlorophentermine hydrochlorideChlorphenterminum [inn-latin]Clorfentermina [inn-spanish]P-chloro-alpha,alpha-dimethylphenethylamine1-(p-Chlorophenyl)-2-methyl-2-aminopropane4-Chloro-alpha,alpha-dimethylbenzeneethanamine
商标名
ApsedonDezopimonClominaEffoxPre-sateLucofenLucofeneNilganaTeramineDesopimon
IUPAC传统名
chlorphentermine
IUPAC标准名
1-(4-chlorophenyl)-2-methylpropan-2-amine
化合物性质
理化性质
疏水性(logP)
2.60 [HANSCH,C ET AL. (1995)]
描述信息
Drug Groups
illicit; experimental; withdrawn
Description
A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
Indication
Used as an appetite suppressant.
Pharmacology
Chlorphentermine is a relatively weak stimulant with little abuse potential. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.
Absorption
Well absorbed following oral administration.
Half Life
40 hours
References
•
GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73.
[Pubmed]
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参考文献
• GYLYS JA, HART JJ, WARREN MR: Chlorphentermine, a new anorectic agent. J Pharmacol Exp Ther. 1962 Sep;137:365-73. Pubmed