物质信息
ID:130939
名称和标识
别名
Ac-Ile-Glu-Pro-Asp-paranitroanilideAc-IEPD-PNAAc-Ile-Glu-Pro-Asp-PNA
IUPAC传统名
(4S)-5-[(2S)-2-{[(1S)-2-carboxy-1-[(4-nitrophenyl)carbamoyl]ethyl]carbamoyl}pyrrolidin-1-yl]-4-[(2S,3S)-2-acetamido-3-methylpentanamido]-5-oxopentanoic acid
IUPAC标准名
(4S)-5-[(2S)-2-{[(1S)-2-carboxy-1-[(4-nitrophenyl)carbamoyl]ethyl]carbamoyl}pyrrolidin-1-yl]-4-[(2S,3S)-2-acetamido-3-methylpentanamido]-5-oxopentanoic acid
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描述信息
A colorimetric substrate for Granzyme B (Kcat/Km = 66000 M-1s-1). Cleavage of pNA is monitored colorimetrically at ~405 nm (e = 9,160 M-1cm-1).
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参考文献
• Harris, J.L. et al., J. Biol. Chem., 273:27364 (1998).
• Thornberry, N.A. et al., Science, 281:1312 (1998).