物质信息
ID:130930
名称和标识
IUPAC传统名
(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-[(4-nitrophenyl)carbamoyl]propanoic acid
IUPAC标准名
(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-[(4-nitrophenyl)carbamoyl]propanoic acid
别名
Ac-Tyr-Val-Ala-Asp-PNAAc-Tyr-Val-Ala-Asp-paranitroanilideAc-Y-V-A-D-PNA
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描述信息
A colorimetric substrate for Caspase-1. Sequence is based on the caspase-1 cleavage site of the IL-1b precursor and includes Asp116. Also a substrate for caspase-4. Cleavage of pNA is monitored colorimetrically at ~405 nm (e = 9,160 M-1cm-1).
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参考文献
• Marcelli, M. et al., Cancer Res., 58:76 (1998).
• Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
• Thornberry, N.A., et al. 1992. Nature 356, 768.
• Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
• Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.