物质信息
ID:130819
名称和标识
IUPAC传统名
methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanamido]-4-carbamoylbutanamido]-4-(methylsulfanyl)butanamido]-5-fluoro-4-oxopentanoate
别名
Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMKZ-D(OMe)QMD(OMe)-FMKZ-Asp(OMe)-Gln-Met-Asp(OMe)-Fluoromethylketone
IUPAC标准名
methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanamido]-4-carbamoylbutanamido]-4-(methylsulfanyl)butanamido]-5-fluoro-4-oxopentanoate
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描述信息
A potent, cell-permeable, and irreversible inhibitor of caspase-3, also recognizes caspase-1. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required.
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参考文献
• Hirata, H. et al., J. Exp. Med., 187(4):587(1998).
• Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.