物质信息
ID:130807
名称和标识
IUPAC标准名
methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoate
别名
Z-Tyr-Val-Ala-Asp(OMe)-FMKZ-YVAD(OMe)-FMKZ-Tyr-Val-Ala-Asp(OMe)-Fluoromethylketone
IUPAC传统名
methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoate
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描述信息
A potent, cell-permeable, and irreversible inhibitor of caspase-1 (ICE), caspase-4, and caspase-5.
分子图谱
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参考文献
• Eldadah, B.A., et al. 1997. J. Neurosci. 17, 6105.
• Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
• Thornberry, N. et al., Persp. in Drug Disc. and Design, 2:389 (1994).