物质信息
ID:130806
名称和标识
别名
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FluoromethylketoneZ-Ile-Glu(OMe)-Thr-Asp(OMe)-FMKZ-IE(OMe)TD(OMe)-FMK
IUPAC标准名
methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate
IUPAC传统名
methyl (3S)-3-[(2S,3R)-2-[(2S)-2-[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-hydroxybutanamido]-5-fluoro-4-oxopentanoate
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描述信息
A potent, cell-permeable, and irreversible inhibitor of caspase-8 and granzyme B. Effectively inhibits influenza virus-induced apoptosis in HeLa cells. Also inhibits granzyme B. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
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参考文献
• Zhuang, S. et al., Exp. Cell. Res., 250(1):203 (1999).