Ac-Asp-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin

名称和标识

别名

Ac-Asp-Glu-Val-Asp-AFCAc-DEVD-AFCAc-Asp-Glu-Val-Asp-7-Amino-4-trifluoromethylcoumarin

IUPAC标准名

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

IUPAC传统名

(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid

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化合物性质

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描述信息

A fluorogenic substrate for Caspase-3 (CPP32, YAMA). Also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10.
Excitation max.: ~400 nm, Emission max.: ~505 nm

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参考文献

• Nicholson, D.W. et al., Nature, 376:37 (1995).

• Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.

• Thornberry, N.A. et al., Science, 281:1312 (1998).

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