物质信息
ID:1289
名称和标识
IUPAC标准名
(1S,2S)-2-amino-1-phenylpropan-1-ol
别名
(1S,2R)-(+)-NorephedrineCathineβ-hydroxyamphetamineD-Cathinenorpseudoephedrine(+)-norephedrinD-norephedrineD-phenylpropanolamineKatine(+)-NorpseudoephedrinePseudonorephedrine
IUPAC传统名
cathine
化合物性质
理化性质
疏水性(logP)
0.83 [SANGSTER (1994)]
溶解度
20 mg/mL at 25 oC [BEILSTEIN]
描述信息
Drug Groups
illicit; experimental
Description
Cathine (β-hydroxyamphetamine) is a monoamine alkaloid found in the shrub Catha edulis (khat). Cathine is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance. [Wikipedia]
Indication
Used to decrease appetite.
Pharmacology
Closely related to ephedrine, cathinone and other amphetamines, it may contribute to the stimulant effect of Catha edulis, although another constituent, cathinone appears to show stronger activity.
Affected Organisms
Humans and other mammals
Absorption
The mucosa of the oral cavity is considered to be the first absorption segment, where the major proportion of the alkaloids is absorbed (mean +/- SD: 84 +/- 6% for cathine). [PMID: 12848785]
Half Life
5.2 +/- 3.4 hours
References
•
Toennes SW, Harder S, Schramm M, Niess C, Kauert GF: Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves. Br J Clin Pharmacol. 2003 Jul;56(1):125-30.
[Pubmed]
External Links
分子图谱
暂无数据
点击上传数据
参考文献
• Toennes SW, Harder S, Schramm M, Niess C, Kauert GF: Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves. Br J Clin Pharmacol. 2003 Jul;56(1):125-30. Pubmed