物质信息
ID:1172
名称和标识
商标名
EposerinCefizox in plastic containerCefizoxCeftixEpocelin
别名
Ceftizoximum [inn-latin]Ceftizoxima [inn-spanish]Ceftizoxime
IUPAC标准名
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
IUPAC传统名
ceftizoxime
化合物性质
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描述信息
Drug Groups
approved
Description
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. [PubChem]
Indication
For the treatment of infections due to susceptible strains of microorganisms.
Pharmacology
Ceftizoxime is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation
Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours.
Protein Binding
30% protein bound
Elimination
Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours.
External Links
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参考文献
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