Drug Groups

approved

Description

Gadodiamide is a gadolinium based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. It is commonly marketed under the trade name Omniscan. [Wikipedia]

Indication

For intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues.

Affected Organisms

Biotransformation

There is no detectable biotransformation or decomposition of gadodiamide.

Half Life

Two-compartment model with mean distribution and elimination half-lives (reported as mean ± SD) of 3.7 ± 2.7 minutes and 77.8 ± 16 minutes, respectively.

Elimination

Gadodiamide is eliminated primarily in the urine.

Distribution

* 200 ± 61 mL/kg

Clearance

* Renal cl=1.7 mL/min/kg
* Plasma cl=1.8 mL/min/kg

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