物质信息

ID:1019

名称和标识
商标名
GlaucolAntidrasiDaranideDasanideOratrol
别名
DichlorophenamideDiclofenamida [INN-Spanish]DichlofenamideDichlorphenamidDichlorphenamideDiclofenamideDiclofenamidum [INN-Latin]
IUPAC传统名
dichlorphenamide
IUPAC标准名
4,5-dichlorobenzene-1,3-disulfonamide
数据登录号
PubChem CID
3038
CAS号
120-97-8
PubChem SID
46505039
化合物性质
理化性质
疏水性(logP)
0.2
描述信息
Drug Groups
approved
Description
A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. [PubChem]
Indication
For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
Pharmacology
Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow).
Affected Organisms
Humans and other mammals
Protein Binding
55%
References
• Tawil R, McDermott MP, Brown R Jr, Shapiro BC, Ptacek LJ, McManis PG, Dalakas MC, Spector SA, Mendell JR, Hahn AF, Griggs RC: Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Ann Neurol. 2000 Jan;47(1):46-53. [Pubmed]
• Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S: [Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences] Eisei Shikenjo Hokoku. 1991;(109):148-50. [Pubmed]
External Links
• [Wikipedia]
• [RxList]
• [Drugs.com]
分子图谱
暂无数据
点击上传数据
参考文献
• Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S: [Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences] Eisei Shikenjo Hokoku. 1991;(109):148-50. Pubmed
• Tawil R, McDermott MP, Brown R Jr, Shapiro BC, Ptacek LJ, McManis PG, Dalakas MC, Spector SA, Mendell JR, Hahn AF, Griggs RC: Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Ann Neurol. 2000 Jan;47(1):46-53. Pubmed
导 航