Drug Groups

approved

Description

Long-acting, broad-spectrum, water-soluble, cephalexin derivative. [PubChem]

Indication

For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes

Pharmacology

Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.

Toxicity

Nausea, vomiting, diarrhoea, allergic rashes may occur

Affected Organisms

Absorption

Cefadroxil is well absorbed on oral administration; food does not interfere with its absorption.

Half Life

1.5 hours

Protein Binding

Binding rates of cefadroxil were 28.1% by U.F. method

Elimination

Over 90% of the drug is excreted unchanged in the urine within 24 hours. It crosses the placenta and appears in breast milk.

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