化合物信息

Drug Groups

illicit; approved; withdrawn

Description

Methyprylon is a sedative of the piperidinedione derivative family. This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with less side effects, such as benzodiazepines. Methyprylon was withdrawn from the US market in June 1965 and the Canadian market in September 1990. [Wikipedia]

Indication

For the treatment of insomnia.

Pharmacology

Methyprylon, a piperidinedione CNS depressant, is close to barbituric acid in structure, but different enough to be called a "non-barbiturate" sedative-hynotic. Methyprylon is used for insomnia and daytime tension. Methyprylon depresses the activity of muscle tissues, the heart, and the respiratory system.

Toxicity

Symptoms of overdose include excitation and convulsions.

Affected Organisms

Biotransformation

Hepatic. Methyprylon is almost completely metabolized.

Half Life

6-16 hours

Protein Binding

60%

References

External Links