化合物信息

Drug Groups

approved

Description

A broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period. [PubChem]

Indication

For the treatment of acute bacterial exacerbations of chronic bronchitis

Pharmacology

Methacycline is a tetracycline antibiotic. Similar to other tetracyclines, it has a wide spectrum of antimicrobial action. It is active against most Gram-positive bacteria (pneumococci, streptococci, staphylococci) and Gram-negative bacteria (E. coli, salmonella, shigella, etc.), and towards agents causing onithosis, psittacosis, trachoma, and some Protozoa. Like other tetracyclines, the general usefulness of methacycline has been reduced with the onset of bacterial resistance.

Affected Organisms

Absorption

58% absorbed

Half Life

14 hours

Protein Binding

75-78% protein bound

References

External Links