化合物信息

S2602 

Research Area: Inflammation
Biological Activity:
Acemetacin (Emflex) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.Acemetacin (Emflex) acts as a prodrug. In the body, acemetacin (Emflex) is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin. Acemetacin (Emflex) is used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. [1][2][3]References on Acemetacin (Emflex)[1] http://en.wikipedia.org/wiki/Acemetacin, , [2] Cochrane Database Syst Rev. , 2009 Jul 8, (3):CD007589[3] Ann Hepatol., 2009 Apr-Jun, 8(2):141-7

02154668 

(1-[p-Chlorobenzoyl]-5-methoxy- 2-methylindole-3-acetic acid carboxymethyl ester)

A1674 

Biochem/physiol Actions
该非甾体抗炎药 (NSAID) 专门增强蒽环类药（阿霉素、柔红霉素和 epirubium）的细胞毒性。避免 MRP 介导的多药耐药性。
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A1674.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

A130700 

Anti-inflammatory.