化合物信息

S2025 

Research Area: Cancer
Biological Activity:
Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. [1] Oral urapidil is effective and well tolerated when used as second-line therapy in patients with blood pressure inadequately controlled with other agents. Urapidil has also been demonstrated to ameliorate glucose and lipid metabolism in hypertensive patients with concomitant diabetes and/or hyperlipidemia. Intravenous urapidil is effective in the treatment of hypertensive crises, perioperative hypertension, and pre-eclampsia and may have a potential role in the management of acute stroke. [2]References on Urapidil HCl[1] Am J Cardiol., 1989, 64(7):1D-6D[2] Adv Ther., 2010, 27(7):426-43

U100 

Biochem/physiol Actions
α1-adrenoceptor antagonist; 5-HT1A serotonin receptor partial agonist; anti-hypertensive.

U815400 

α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.