An antibiotic produced by Streptomyces fradiae. [PubChem]
Indication
For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
Pharmacology
Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.
Toxicity
LD50>5 g/kg (rats). Side effects may include diarrhea
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation
No transformation, excreted unchanged
Absorption
Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%
Half Life
5.7 (± 2.8) hours. The elimination half-life is 40 hours in anuric patients undergoing hemodialysis.
Protein Binding
0% (not bound to plasma proteins)
Elimination
Fosfomycin is excreted unchanged in both urine and feces.
