化合物信息

S2337 

Research Area: Endocrinology
Biological Activity:
Osthole(Osthol) is a type of coumarin. Osthole is found in cnidium monnieri and several other plants. Osthol may increase androgen,gonadotropin and nitric oxide synthase (NOS) activity. One mouse study indicates osthol had androgen like effect and gonadotropin like effect. [1]

O9265 

Biochem/physiol Actions
Active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Dramatically decreased lipid accumulation in a quail model.1 Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of neurodegenerative disorders.2 Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.3
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. O9265.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.