基本信息

化学结构

分子式

C₉H₁₃N

分子量

135.20622

精确质量

135.10479942

电荷

InChI

InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1

InChIKey

KWTSXDURSIMDCE-QMMMGPOBSA-N

Canonic Smiles

C[C@@H](Cc1ccccc1)N

Isomeric Smiles

N[C@H](Cc1ccccc1)C

计算属性

JChem

质子受体

质子供体

LogD (pH = 5.5)

-1.2147744

LogD (pH = 7.4)

-0.67093694

Log P

1.8042505

摩尔折射率

43.7052

极化性

17.364613

极化表面积

26.02

可自由旋转的化学键

里宾斯基五规则

true

ALOGPS 2.1

Log P

1.85

LOG S

-1.89

溶解度

1.74e+00 g/l

数据来源

名称和标识

商标名

DexidrineDexedrineDephadrenAmsustainDextrostatDesoxynDexacapsSympaminDexadrineDexedrine SpansuleElastononFinamAnorexideOrtedrineParedrineDexampexRaphetamineIsoamyneProfaminaAdipanIsomynSimpatedrinMecodrinBenzedrinePercomonMethampexSimpatinaPhenamineNorephedraneOktedrinIsoamycinRhinalatorBenzoloneAllodeneBenzebarFenaminPhenedrineAnorexineSympatedrinePsychedrineFerndexWeckamineActedronNovydrineSympaminePropisamine

别名

D-1-Phenyl-2-aminopropaneDexamfetaminum [inn-latin](+)-alpha-methylphenethylamine(s)-alpha-methylphenethylamine(s)-amphetamineD-2-Amino-1-phenylpropane(S)-1-Phenyl-2-propanamineDextroamphetamine sulfate(2S)-1-phenylpropan-2-amine(2S)-(+)-AmphetamineD-amDextroamphetamine(+)-amphetamineD-1-Phenyl-2-aminopropanD-(+)-amphetamineS(+)-amphetamine(s)-(+)-amphetamineDexamfetamineD-amphetamineDexamphetaminum [inn-latin]Dexamfetamina [inn-spanish](+)-phenaminumDexamphetamineD-(s)-amphetamine(S)-1-phenyl-2-propylamined-1-Phenyl-2-aminopropan [German]D-alpha-methylphenethylamine(s)-alpha-phenylethylamine(S)-1-phenyl-2-aminopropane(s)-(+)-beta-phenylisopropylamineDexanfetamina [inn-spanish]

IUPAC传统名

dextroamphetamine amphetamine

IUPAC标准名

(2S)-1-phenylpropan-2-amine

IUPAC系统名

(2S)-1-phenylpropan-2-amine

名称和标识

数据登录号

CAS号

ATC码

DrugBank ID

KEGG ID

EC号

PubChem CID

CHEMBL

Chemspider ID

Beilstein号

医学主题词(MeSH)

维基百科标题

美国药典/FDA物质标识码

CHEBI ID

Gmelin ID

PubChem SID

数据登录号

化合物性质

理化性质

溶解度

Slightly

疏水性(logP)

1.8

1.76 [SANGSTER (1994); similar isomer]

分配系数

1.789

化合物性质

分子相关蛋白质

暂无数据

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分子相关蛋白质

分子图谱

暂无数据

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描述信息

参考文献

PubChem文献

数据源提供

• Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. Pubmed

• Chaudhry IA, Turkanis SA, Karler R: Characteristics of "reverse tolerance" to amphetamine-induced locomotor stimulation in mice. Neuropharmacology. 1988 Aug;27(8):777-81. Pubmed

• Sax KW, Strakowski SM: Behavioral sensitization in humans. J Addict Dis. 2001;20(3):55-65. Pubmed

• Leith NJ, Kuczenski R: Chronic amphetamine: tolerance and reverse tolerance reflect different behavioral actions of the drug. Pharmacol Biochem Behav. 1981 Sep;15(3):399-404. Pubmed

• Wagner GJ, Rabkin R: Effects of dextroamphetamine on depression and fatigue in men with HIV: a double-blind, placebo-controlled trial. J Clin Psychiatry. 2000 Jun;61(6):436-40. Pubmed

• Yamada H, Baba T, Hirata Y, Oguri K, Yoshimura H: Studies on N-demethylation of methamphetamine by liver microsomes of guinea-pigs and rats: the role of flavin-containing mono-oxygenase and cytochrome P-450 systems. Xenobiotica. 1984 Nov;14(11):861-6. Pubmed

• Martinsson L, Yang X, Beck O, Wahlgren NG, Eksborg S: Pharmacokinetics of dexamphetamine in acute stroke. Clin Neuropharmacol. 2003 Sep-Oct;26(5):270-6. Pubmed

• Butefisch CM, Davis BC, Sawaki L, Waldvogel D, Classen J, Kopylev L, Cohen LG: Modulation of use-dependent plasticity by d-amphetamine. Ann Neurol. 2002 Jan;51(1):59-68. Pubmed

• Warneke L: Psychostimulants in psychiatry. Can J Psychiatry. 1990 Feb;35(1):3-10. Pubmed

参考文献

生物活性

PubChem BioAssay

生物活性