Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Research Area: Neurological Disease Biological Activity: Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents.In inhibits prolactin release inhibitory factor, thus stimulating the release of prolactin. The turnover of dopamine in the brain is also increased. [1] Chlorpromazine blocks a variety of K+ channels in heart muscle cells. Inasmuch as the potency of inhibition is less than the previously reported use-dependent block of Na+ channels, the cardiovascular adverse effects of chlorpromazine are probably caused mainly by the latter effect. [2]
Hydrochloride Reported to be useful as a substitute for benzidine, o-dianisidine and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.
Application 在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。 Biochem/physiol Actions 吩噻嗪类抗精神病药;D2 多巴胺受体拮抗剂，H1 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯酶和一氧化氮合成酶的活化。 氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性，但是不会影响正常淋巴细胞的活力。 Other Notes Uncouples and inhibits oxidative phoshorylation at 10-3-10-4 M1,2; Interaction of phenothiazine antipsychotics with calmodulin3
有毒 (T)
剧毒 (T+)