化合物信息

Drug Groups

approved

Description

An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. [PubChem]

Indication

For the treatment of petit mal epilepsy.

Pharmacology

Used in the treatment of epilepsy. Ethosuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli.

Toxicity

Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression.

Affected Organisms

Biotransformation

Hepatic, via CYP3A4 and CYP2E1.

Absorption

Bioavailability following oral administration is 93%.

Half Life

53 hours

References

External Links