化合物信息

Drug Groups

approved

Description

Fesoterodine is an antimuscarinic prodrug used for treating overactive bladder syndrome.

Indication

For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).

Pharmacology

Fesoterodine is a prodrug. In vivo it is broken down into its active metabolite, 5-hydroxymethyl tolterodine, by plasma esterases. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Therefore, acting as a competitive muscarinic receptor antagonist, fesoterodine ultimately acts to decrease the detrusor pressure by its muscarinic antagonism, thereby decreasing bladder contraction and consequently, the urge to urinate.

Affected Organisms

Half Life

7-8 hours for the active metabolite.

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