化合物信息

Drug Groups

approved

Description

A tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.

Indication

For the treatment of depression.

Pharmacology

Mianserin is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. It is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. Mianserin may cause drowsiness and hematological problems.

Toxicity

Oral rat LD₅₀: 780mg/kg

Affected Organisms

Biotransformation

Hepatic.

Absorption

Absorbed following oral administration.

Half Life

10-17 hours

Protein Binding

90%

References

External Links