CAS 150-25-4|N,N-bis [2-hydroxyethyl]glycine|Bicine|2-[bis(2-hydroxyethyl)amino]acetic acid|bicine|DIHYDROXYETHYLGLYCINE|N,N-双(2-羟乙基)甘氨酸|BICINE|Dihydroxyethylglycine|<i>N</i>,<i>N</i>-Bis(2-h...

基本信息

化学结构

分子式

C₆H₁₃NO₄

分子量

163.17172

精确质量

163.0844579

电荷

InChI

InChI=1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)

InChIKey

FSVCELGFZIQNCK-UHFFFAOYSA-N

Canonic Smiles

OCCN(CC(=O)O)CCO

Isomeric Smiles

OCCN(CCO)CC(=O)O

计算属性

JChem

LogD (pH = 7.4)

-4.69

LogD (pH = 5.5)

-3.88

Log P

-3.85

可自由旋转的化学键

质子供体

质子受体

里宾斯基五规则

true

Acid pKa

3.00

极化表面积

81.00

极化性

16.33

摩尔折射率

38.66

LOG S

0.97

数据来源

名称和标识

别名

N,N-bis [2-hydroxyethyl]glycineBicineDIHYDROXYETHYLGLYCINEN,N-双(2-羟乙基)甘氨酸BICINEDihydroxyethylglycineN,N-Bis(2-hydroxyethyl)glycineDiethylolglycineDiethanol glycineN,N-Bis(2-hydroxyethyl)glycineBICINE 30% PEG 600 solutionPEG Grid Screening Solution 24/Fluka kit no 36436BICINE2-(bis(2-hydroxyethyl)amino)acetic acidBICINE buffer SolutionN,N-Di(2-hydroxyethyl)glycineN,N-二(2-羟乙基)甘氨酸N,N-bis(2-hydroxyethyl)glycineBicinebicine buffer

IUPAC标准名

2-[bis(2-hydroxyethyl)amino]acetic acid

IUPAC传统名

bicine

名称和标识

数据登录号

EC号

MDL号

CAS号

Beilstein号

PubChem SID

248881052484891624892086465059802489173816096680426697204

DrugBank ID

DB03709

CHEMBL

1231251

维基百科标题

Bicine

CHEBI ID

39066CHEBI:40957CHEBI:39064CHEBI:40950

Chemspider ID

8431

默克索引号

141201

PubChem CID

8761

PDB数据库

2x7w3sap6ldl4oyn4hn47o1z7cts2a813h7q7w1n5ele1ltm3u696t815dog5ll4

Gmelin ID

3532

专利号

US2007166276US2005003448EP1849461US2005214885WO2006036885US2004037802EP1473299US2006148042EP0950660WO2007127330

Reaxys Registry

1769362

PDBeChem数据库

BCN

MetaboLights数据库

MTBLS49MTBLS739MTBLS1115MTBLS751

CompTox数据库

SureChEMBL数据库

PubMed文献链接

ACToR数据库

HMDB数据库

数据登录号

化合物性质

分子相关蛋白质

分子图谱

暂无数据

点击上传数据

描述信息

DrugBank

DB03709

Drug information: experimental

MP Biomedicals

02151490

Purity: ~98%
White crystals or powder
Chelating agent

02101005

pKa = 8.3 at 25°C
Useful pH range 7.6-9.0

Wikipedia

Bicine

Sigma Aldrich

B3876

Application
低温生化作业的推荐缓冲液。1用于制备测定血清鸟嘌呤酶的稳定底物溶液。2采用交联葡聚糖通过等速电泳对血浆蛋白进行分级分离中的间隔臂。3
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. B3876.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

B8660

Application
低温生化作业的推荐缓冲液。1用于制备测定血清鸟嘌呤酶的稳定底物溶液。2采用交联葡聚糖通过等速电泳对血浆蛋白进行分级分离中的间隔臂。3

14844

14871

Application
低温生化作业的推荐缓冲液。1用于制备测定血清鸟嘌呤酶的稳定底物溶液。2采用交联葡聚糖通过等速电泳对血浆蛋白进行分级分离中的间隔臂。3
BICINE can be used to study biological buffers and zwitterionic compounds. N,N-Bis(2-hydroxyethyl)glycine has been used in a study that characterized refined crystal structures of human Ca2+/Zn2+-binding S100A3 protein. N,N-Bis(2-hydroxyethyl)glycine has also been used in a study to inform F1 antigen assembly.

14872

ChEBI

CHEBI:40957

A bicine that is a Good's buffer substance, pKa = 8.35 at 20 degreeC.

描述信息

参考文献

PubChem文献

数据源提供

• Biological buffer, pK _a = 8.35 at 20 ^o : Biochemistry, 5, 467 (1966).

参考文献

生物活性

PubChem BioAssay