CAS 70-18-8|CAS 98726-08-0|(2<i>S</i>)-2-Amino-5-[[(2<i>R</i>)-1-(carboxymethylamino)-1-oxo- 3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid|glutathione|(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carb...

(2S)-2-Amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo- 3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acidGlutathioneγ-L-Glutamyl-L-cysteinylglycineγ-L-Glutamyl-L-cysteinyl-glycineL-还原型谷胱甘肽GSH5-L-谷氨酰-L-半胱氨酰甘氨酸L-Glutathione reduced5-L-Glutamyl-L-cysteinylglycinegamma-L-Glutamyl-L-cysteinyl-glycineN-(N-gamma-L-Glutamyl-L-cysteinyl)glycineGluthathioneL-GlutathioneTathionGlutideL-γ-Glutamyl-L-cysteinyl-glycineAgifutol SGlutinalGlutathione-SHTathioneGlutathionIsethionReduced glutathioneBakezyme RXTriptideL-GlutathioneDeltathioneNeuthionCoprengamma-L-Glutamyl-L-cysteinylglycineL-谷胱甘肽, reducedL-Glutathione, reducedgamma-L-Glutamyl-L-cysteinyl-glycineglutathioneGSH5-L-Glutamyl-L-cysteinylglycineGlutathioneReduced glutathioneGlutathione-SHN-(N-gamma-L-Glutamyl-L-cysteinyl)glycinephytochelatinsphytochelatin

商标名

NeuthionIsethionTathionCoprenLedac

API名称

Glutathione

名称和标识

数据登录号

MDL号

Beilstein号

EC号

CAS号

PubChem SID

2489524124895261160963492465045982489516411533291104222367

医学主题词(MeSH)

Chemspider ID

KEGG ID

PubChem CID

DrugBank ID

ATC码

CHEBI ID

60836CHEBI:12402CHEBI:5437CHEBI:24334CHEBI:43049CHEBI:42873CHEBI:14327CHEBI:16856CHEBI:60836

CHEMBL

1543CHEMBL1543

美国药典/FDA物质标识码

GAN16C9B8O

默克索引号

144475

维基百科标题

GlutathionePhytochelatin

PubMed文献链接

1958082316391576164044761678023782072091662173847456544200890149884351611241616877380136295617439666166503981631693110577998

BKMS React数据库

3073530912294892282919169154427593537082294884494256

BRENDA数据库

4.1.1.325.1.1.15.3.4.13.5.3.91.13.11.272.3.1.652.7.1.562.7.1.825.3.99.43.1.4.172.1.1.22.4.1.12.7.1.943.4.22.246.2.1.1

KNApSAcK数据库

C00001518

BRENDA Ligand数据库

593154427910479524693826537081061959169951673091449344312323394256

PDB数据库

1grx1hnl1qgj2imi4al05f066f662brq3zmk1m0u5aiv2pmt2wb93khq3m3m4kf9

MetaboLights数据库

MTBLS530MTBLS1044MTBLS2870MTBLS4579MTBLS405MTBLS8MTBLS868MTBLS1040MTBLS1801MTBLS4495MTBLS2274MTBLS158MTBLS3038MTBLS3657MTBLS419

Reaxys Registry

1729812

MetaCyc数据库

GLUTATHIONE

CompTox数据库

DTXSID6023101

SABIO-RK数据库

103291617061118721349833101187592695771078013721972118701210210291

UniProt数据库

P14141Q3KJQ5P0C291Q9I4K6Q0I5A5Q61846O23264P48638Q5RBL6B7UHB1A9N563Q601Q3Q5QLR2C0Q0D3Q8XA20

专利号

EP1961418EP1070710EP1829551WO2007103435EP1790238US2007191281US2008274888US2005130904WO2007109633EP1712220WO2007135242US2003207344EP1917969WO2007116428

Reactom Database

R-HSA-9035966R-HSA-1247915R-HSA-3323079R-HSA-3301943R-HSA-6799695R-HSA-3341397R-HSA-1500817R-HSA-1655879R-HSA-8943279R-HSA-5693724R-HSA-2161660R-HSA-9011595R-HSA-176059R-HSA-3323013

BioModels数据库

BIOMD0000000450BIOMD0000000575BIOMD0000000674BIOMD0000000547BIOMD0000000609BIOMD0000000589BIOMD0000000353BIOMD0000000268BIOMD0000000070BIOMD0000000474BIOMD0000000624BIOMD0000001061

IntAct数据库

EBI-21945658EBI-27072957EBI-21986471EBI-21945552EBI-27072995EBI-11301756EBI-11301741EBI-21945598EBI-27072856EBI-21981648

PDBeChem数据库

GSH

EnzymePortal数据库

P95806B0LDU5P83654P31663Q12068

FooDB数据库

FDB001498

Drug Central Database

KEGG DRUG Database

SureChEMBL数据库

HMDB数据库

GeneOntology数据库

GO:0071993GO:0046937GO:0046938GO:0071995GO:0044604GO:0071994

数据登录号

化合物性质

分子相关蛋白质

分子相关蛋白质

分子图谱

暂无数据

点击上传数据

描述信息

DrugBank

DB00143

Drug Groups

approved; nutraceutical

Description

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. [PubChem]

Indication

For nutritional supplementation, also for treating dietary shortage or imbalance

Toxicity

ORL-MUS LD₅₀ 5000 mg/kg, IPR-MUS LD₅₀ 4020 mg/kg, SCU-MUS LD₅₀ 5000 mg/kg, IVN-RBT LD₅₀ > 2000 mg/kg, IMS-MUS LD₅₀ 4000 mg/kg

Affected Organisms

Humans and other mammals

Absorption

Research suggests that glutathione is not orally bioactive, and that very little of oral glutathione tablets or capsules is actually absorbed by the body.

References

• Struzynska L, Chalimoniuk M, Sulkowski G: The role of astroglia in Pb-exposed adult rat brain with respect to glutamate toxicity. Toxicology. 2005 Sep 1;212(2-3):185-94. [Pubmed]

• Witschi A, Reddy S, Stofer B, Lauterburg BH: The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43(6):667-9. [Pubmed]

• Yim CY, Hibbs JB Jr, McGregor JR, Galinsky RE, Samlowski WE: Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J Immunol. 1994 Jun 15;152(12):5796-805. [Pubmed]

• Drevet JR: The antioxidant glutathione peroxidase family and spermatozoa: a complex story. Mol Cell Endocrinol. 2006 May 16;250(1-2):70-9. Epub 2006 Jan 19. [Pubmed]

• Wu G, Fang YZ, Yang S, Lupton JR, Turner ND: Glutathione metabolism and its implications for health. J Nutr. 2004 Mar;134(3):489-92. [Pubmed]

External Links

• [Wikipedia]

• [PDRhealth]

Wikipedia

Glutathione

Sigma Aldrich

G4705

Amino Acid Sequence
γ-Glu-Cys-Gly
Application
可用 5-10mM 浓度的产品从谷胱甘肽琼脂糖中洗提谷胱甘肽 S-转移酶 (GST)。
生物抗氧化剂1，已与抗肿瘤剂共同用于提高活性2或者降低副作用。3
Biochem/physiol Actions
在细胞代谢和突发性呼吸期间形成的活性氧还原中发挥重要作用的内源性抗氧化剂。谷胱甘肽-S-转移酶催化谷胱甘肽硫醚与异生物、白三烯和其他具有亲电中心的分子的形成。谷胱甘肽还与蛋白质中半胱氨酸残基形成二硫键。通过这些机制，它可具有降低抗癌剂效用的奇异效果。

G6013

Amino Acid Sequence
γ-Glu-Cys-Gly
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
可用 5-10mM 浓度的产品从谷胱甘肽琼脂糖中洗提谷胱甘肽 S-转移酶 (GST)。
Biochem/physiol Actions
在细胞代谢和突发性呼吸期间形成的活性氧还原中发挥重要作用的内源性抗氧化剂。谷胱甘肽-S-转移酶催化谷胱甘肽硫醚与异生物、白三烯和其他具有亲电中心的分子的形成。谷胱甘肽还与蛋白质中半胱氨酸残基形成二硫键。通过这些机制，它可具有降低抗癌剂效用的奇异效果。

49750

Amino Acid Sequence
γ-Glu-Cys-Gly
Application
可用 5-10mM 浓度的产品从谷胱甘肽琼脂糖中洗提谷胱甘肽 S-转移酶 (GST)。
Biochem/physiol Actions
在细胞代谢和突发性呼吸期间形成的活性氧还原中发挥重要作用的内源性抗氧化剂。谷胱甘肽-S-转移酶催化谷胱甘肽硫醚与异生物、白三烯和其他具有亲电中心的分子的形成。谷胱甘肽还与蛋白质中半胱氨酸残基形成二硫键。通过这些机制，它可具有降低抗癌剂效用的奇异效果。

G6529

Amino Acid Sequence
γ-Glu-Cys-Gly
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
可用 5-10mM 浓度的产品从谷胱甘肽琼脂糖中洗提谷胱甘肽 S-转移酶 (GST)。
Biochem/physiol Actions
在细胞代谢和突发性呼吸期间形成的活性氧还原中发挥重要作用的内源性抗氧化剂。谷胱甘肽-S-转移酶催化谷胱甘肽硫醚与异生物、白三烯和其他具有亲电中心的分子的形成。谷胱甘肽还与蛋白质中半胱氨酸残基形成二硫键。通过这些机制，它可具有降低抗癌剂效用的奇异效果。

G4251

Amino Acid Sequence
γ-Glu-Cys-Gly
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
可用 5-10mM 浓度的产品从谷胱甘肽琼脂糖中洗提谷胱甘肽 S-转移酶 (GST)。
Biochem/physiol Actions
在细胞代谢和突发性呼吸期间形成的活性氧还原中发挥重要作用的内源性抗氧化剂。谷胱甘肽-S-转移酶催化谷胱甘肽硫醚与异生物、白三烯和其他具有亲电中心的分子的形成。谷胱甘肽还与蛋白质中半胱氨酸残基形成二硫键。通过这些机制，它可具有降低抗癌剂效用的奇异效果。
包装
1, 5, 10, 25, 50, 100, 250, 500 g in poly bottle
300 mg in poly bottle
10 mg in autosmp vl

TRC

G597951

Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione production is regulated via distinct pathways in stre

ChEBI

CHEBI:16856

A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.

CHEBI:60836

A family of peptides related to glutathione and composed of (gamma-Glu-Cys)n-Gly where n is in the range 2-11.

描述信息

参考文献

PubChem文献

数据源提供

• Wu G, Fang YZ, Yang S, Lupton JR, Turner ND: Glutathione metabolism and its implications for health. J Nutr. 2004 Mar;134(3):489-92. Pubmed

• Yim CY, Hibbs JB Jr, McGregor JR, Galinsky RE, Samlowski WE: Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J Immunol. 1994 Jun 15;152(12):5796-805. Pubmed

• Struzynska L, Chalimoniuk M, Sulkowski G: The role of astroglia in Pb-exposed adult rat brain with respect to glutamate toxicity. Toxicology. 2005 Sep 1;212(2-3):185-94. Pubmed

• Witschi A, Reddy S, Stofer B, Lauterburg BH: The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43(6):667-9. Pubmed

• Drevet JR: The antioxidant glutathione peroxidase family and spermatozoa: a complex story. Mol Cell Endocrinol. 2006 May 16;250(1-2):70-9. Epub 2006 Jan 19. Pubmed

• Misko, T., et al.: J. Biol. chem., 273, 15646 (1998)

• Nakamura, K., et al.: J. Biol. Chem., 276, 34402 (1998)

• Burdo, J., et al.: Brain Res. 1189, 12 (2008).

参考文献

生物活性

PubChem BioAssay

生物活性

化合物信息

ID:29