• Readily forms ?-lactam derivatives whichare valuable intermediates for the synthesis of a variety of products, including thienamycin: J. Am. Chem. Soc., 102, 6163 (1980); Tetrahedron Lett., 23, 2293 (1982).
生物活性
PubChem BioAssay
化合物性质
理化性质
溶解度
4.5 g/l
H2O: soluble5 mg/mL
0.5 M HCl: soluble50 mg/mL (with heat)
1 M NaOH: soluble50 mg/mL
1 M HCl: soluble0.5 M at 20 °C, clear, colorless
1 M HCl: soluble100 mg/mL
1 M HCl: soluble50 mg/mL
-3.7
270-271
270-271°C
>300 °C (dec.)(lit.)
>300°C dec.
[α]20/D +25°, c = 8 in 5 M HCl
[α]/D 24.0 to 26.0°, c = 8 in hydrochloric acid (6 N HCl)
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. [PubChem]
Indication
There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.
Pharmacology
L-aspartate is considered a non-essential amino acid, meaning that, under normal physiological conditions, sufficient amounts of the amino acid are synthesized in the body to meet the body's requirements. L-aspartate is formed by the transamination of the Krebs cycle intermediate oxaloacetate. The amino acid serves as a precursor for synthesis of proteins, oligopeptides, purines, pyrimidines, nucleic acids and L-arginine. L-aspartate is a glycogenic amino acid, and it can also promote energy production via its metabolism in the Krebs cycle. These latter activities were the rationale for the claim that supplemental aspartate has an anti-fatigue effect on skeletal muscle, a claim that was never confirmed.
Toxicity
Mild gastrointestinal side effects including diarrhea. LD50 (rat) > 5,000 mg/kg.
Affected Organisms
Humans and other mammals
Absorption
Absorbed from the small intestine by an active transport process
Biochem/physiol Actions 快速突触兴奋的主要神经递质。 L-Aspartic acid is a negatively charged carboxyl side-chain containing α amino acid. Aspartic acid is involved in nitrogen metabolism via its inter-conversion to oxaloacetate (OAA). As one of the 22 proteinogenic amino acids L-Asp is incorporated into proteins by translation processes in vitro. L-Aspartic acid is a non-essential amino acid added to cell culture media. L-aspartate supports polyamine biosynthesis.
刺激性 (Xi)