CAS 34787-01-4|Ticarcilina [inn-spanish]|Ticarcillinum [inn-latin]|Ticarcilline [inn-french]|(2S,5R,6R)-6-[(2R)-2-carboxy-2-(thiophen-3-yl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hep...

基本信息

化学结构

分子式

C₁₅H₁₆N₂O₆S₂

分子量

384.42734

精确质量

384.04497824

电荷

InChI

InChI=1S/C15H16N2O6S2/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23)/t7-,8-,9+,12-/m1/s1

InChIKey

OHKOGUYZJXTSFX-KZFFXBSXSA-N

Canonic Smiles

O=C([C@@H](c1cscc1)C(=O)O)N[C@@H]1C(=O)N2[C@@H]1SC([C@@H]2C(=O)O)(C)C

Isomeric Smiles

S1[C@H]2N([C@H](C1(C)C)C(=O)O)C(=O)[C@H]2NC(=O)[C@@H](c1ccsc1)C(=O)O

计算属性

JChem

Acid pKa

3.0920584

质子受体

质子供体

LogD (pH = 5.5)

-3.1756372

LogD (pH = 7.4)

-5.9742513

Log P

0.5957988

摩尔折射率

87.9253

极化性

34.58174

极化表面积

124.01

可自由旋转的化学键

里宾斯基五规则

true

ALOGPS 2.1

Log P

0.99

LOG S

-3.73

溶解度

7.16e-02 g/l

数据来源

学术数据

产品目录

数据来源

名称和标识

别名

Ticarcilina [inn-spanish]Ticarcillinum [inn-latin]Ticarcilline [inn-french]TicarcillinTicarcillin supplement替卡西林添加剂Ticarcillin Supplement替卡西林Ticarcillin

IUPAC标准名

(2S,5R,6R)-6-[(2R)-2-carboxy-2-(thiophen-3-yl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

IUPAC传统名

ticarcillin

名称和标识

数据登录号

PubChem SID

4650595916096484424850647

CAS号

PubChem CID

MDL号

EC号

数据登录号

化合物性质

产品相关信息

级别

for microbiology

有效期

(limited shelf life, expiry date on the label)

Empirical Formula (Hill Notation)

C15H16N2O6S2

化合物性质

分子相关蛋白质

暂无数据

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分子图谱

暂无数据

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描述信息

DrugBank

DB01607

Drug Groups

approved

Description

An antibiotic derived from penicillin similar to carbenicillin in action.

Indication

For the treatment of bacterial infections.

Pharmacology

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ?-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.

Toxicity

As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.

Affected Organisms

Enteric bacteria and other eubacteria

Half Life

1.1 hours

Protein Binding

45%

External Links

• [Wikipedia]

• [RxList]

• [Drugs.com]

Sigma Aldrich

17778

Components
组分（每瓶足够用于 1000mL 培养基）：替卡西林 1.00mg
Application
推荐用于选择性增菌小肠结肠炎耶尔森菌的抗生素添加剂。

描述信息

参考文献

PubChem文献

暂无数据

点击上传数据

参考文献

生物活性

PubChem BioAssay

生物活性

数据来源

学术数据

产品目录

名称和标识

别名

Ticarcilina [inn-spanish]Ticarcillinum [inn-latin]Ticarcilline [inn-french]TicarcillinTicarcillin supplement替卡西林添加剂Ticarcillin Supplement替卡西林Ticarcillin

IUPAC标准名

(2S,5R,6R)-6-[(2R)-2-carboxy-2-(thiophen-3-yl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

IUPAC传统名

ticarcillin

数据登录号

PubChem SID

4650595916096484424850647

CAS号

PubChem CID

MDL号

EC号

化合物性质

产品相关信息

级别

for microbiology

有效期

(limited shelf life, expiry date on the label)

Empirical Formula (Hill Notation)

C15H16N2O6S2

描述信息

DrugBank

DB01607

Drug Groups

approved

Description

An antibiotic derived from penicillin similar to carbenicillin in action.

Indication

For the treatment of bacterial infections.

Pharmacology

Toxicity

As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.

Affected Organisms

Enteric bacteria and other eubacteria

Half Life

1.1 hours

Protein Binding

45%

External Links

• [Wikipedia]

• [RxList]

• [Drugs.com]

Sigma Aldrich

17778