化合物信息

Drug Groups

approved

Description

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with cilastatin, a renal dipeptidase inhibitor. [PubChem]

Indication

For the treatment of bacterial infections caused by susceptible bacteria.

Pharmacology

Imipenem is a beta-lactam antibiotic belongings to the subgroup of carbapenems. Imipenem has a broad spectrum of activity against aerobic and anaerobic Gram positive as well as Gram negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase when administered alone, and is always co-administered with cilastatin to prevent this inactivation.

Affected Organisms

Biotransformation

Renal.

Absorption

Imipenem is not effectively absorbed from the gastrointestinal tract and therefore must be administered parenterally.

Half Life

1 hour

Protein Binding

20% binds to plasma proteins

References

External Links