CAS 57-85-2|丙酸睾酮|androgen|(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.02,7.011,15]heptadec-6-en-14-yl propanoate...

基本信息

化学结构

分子式

C₂₂H₃₂O₃

分子量

344.48768

精确质量

344.23514488

电荷

InChI

InChI=1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1

InChIKey

PDMMFKSKQVNJMI-BLQWBTBKSA-N

Canonic Smiles

CCC(=O)O[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C

Isomeric Smiles

O([C@@H]1[C@@]2([C@H]([C@H]3[C@@H]([C@@]4(C(=CC(=O)CC4)CC3)C)CC2)CC1)C)C(=O)CC

计算属性

JChem

Acid pKa

19.086855

质子受体

质子供体

LogD (pH = 5.5)

4.5070844

LogD (pH = 7.4)

4.5070844

Log P

4.5070844

摩尔折射率

98.2082

极化性

38.92798

极化表面积

43.37

可自由旋转的化学键

里宾斯基五规则

true

ALOGPS 2.1

Log P

3.65

LOG S

-4.84

溶解度

5.02e-03 g/l

数据来源

名称和标识

别名

丙酸睾酮4-Androsten-17β-ol-3-one 17-propionate17β-Hydroxy-4-androsten-3-one 17-propionate17β-Propionyloxy-4-androsten-3-oneTestosterone propionateTestosterone PropionateEnarmonAquavironAndrotest PNSCAndrotestonHormotestonNRB 03689AndrolonBio-testiculina(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate丙酸睾丸素Testosteroni propionas(17β)-17-(1-Oxopropoxy)androst-4-en-3-oneTestodrinTestosterone-17-propionateVirormoneTestoviron17β-(Propionyloxy)androst-4-en-3-oneTestrexAgovirin

IUPAC传统名

androgen testosterone propionate

IUPAC标准名

(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-yl propanoate (1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl propanoate

商标名

TestexAgovirin

名称和标识

数据登录号

EC号

CAS号

Beilstein号

MDL号

PubChem SID

248999942488869216096468846508693

PubChem CID

5995

数据登录号

化合物性质

药理学性质

作用靶点

Androgen Receptor / Estrogen receptor

相关基因信息

human ... CYP17A1(1586)rat ... Ar(24208)

理化性质

溶解度

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble4.4 mg/mL

H2O: insoluble

ethanol: soluble10 mg/mL

外观

white solid

比旋光度

[α]20/D +86±3°, c = 2% in dioxane

熔点

118-123 °C

化合物性质

分子相关蛋白质

暂无数据

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分子图谱

暂无数据

点击上传数据

描述信息

Selleck Chemicals

S2558

Biological Activity:
Testosterone propionate (Agovirin) is a direct androgen receptor activator and an indirect certain estrogen receptors activator. Testosterone propionate (Agovirin) increases the level of the IGF-1 hormone which leads to muscle growth. Testosterone propionate (Agovirin) has been used for the increase of the nitrogen in the muscles and this leads to the increase of the proteins in the muscles as well. When the muscle fibers have a lot of proteins, they increase in size and quality. As with other testosterones, testosterone propionate (Agovirin) leads to the increase in the activity of the satellite cells which leads to faster recovery after exercising among others. Testosterone propionate (Agovirin) also prevents muscles from wasting and maintains the quality of the muscles you have gained for some time. When testosterone propionate (Agovirin) comes to fat loss, testosterone propionate (Agovirin) is a leader as testosterone propionate (Agovirin) promotes muscle gain and fat loss. [1][2][3]References on Testosterone propionate (Agovirin)[] TEM, 1998, 9:317-324

DrugBank

DB01420

Drug Groups

approved

Description

An ester of testosterone with a propionate substitution at the 17-beta position. [PubChem]

Indication

Testosterone propionate is an anabolic steroid and a short ester form of testosterone that becomes active in the body. It is often used for muscle mass building.

Pharmacology

Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted from the testes of males. In females, it is produced in the ovaries, adrenal glands and by conversion of adrostenedione in the periphery. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone than an adult female's body does. In the body, this ester form of testosterone is hydrolyzed rapidly and become actively available as testosterone.

Toxicity

Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.

Affected Organisms

Humans and other mammals

Biotransformation

Testosterone propionate is rapidly hydrolysed into testosterone. Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).

Protein Binding

40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins.

Elimination

About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6% of a dose is excreted in the feces, mostly in the unconjugated form.

External Links

• [Drugs.com]

MP Biomedicals

05218655

MP Biomedicals Rare Chemical collection

Sigma Aldrich

T1875

Biochem/physiol Actions
Androgen.
Physical form
Photosensitive solid

86540

Other Notes
Sales restrictions may apply

86541

Other Notes
可能实行销售限制

46925

法律信息
VETRANAL 商标 Sigma-Aldrich Co. LLC

TRC

T155045

Anabolic steroid. Androgen.Controlled substance.

描述信息

参考文献

PubChem文献

数据源提供

• http://en.wikipedia.org/wiki/Testosterone

• Nieschlag, E., et al.: Steroids, 68, 965 (1977)

• Wang, C., et al.: J. Clin. Endocrinol. Metab., 91, 460 (1977)

• Behre, H., et al.: Eur. J. Endocrinol., 140, 414 (1977)

• Glass, A., et al.: J. Clin. Endocrinol. Metab., 45, 1211 (1977)

参考文献

生物活性

PubChem BioAssay

生物活性

名称和标识

别名

IUPAC传统名

androgen testosterone propionate

IUPAC标准名

商标名

TestexAgovirin

数据登录号

EC号

CAS号

Beilstein号

MDL号

PubChem SID

248999942488869216096468846508693

PubChem CID

5995

描述信息

Selleck Chemicals

S2558

DrugBank

DB01420

Drug Groups

approved

Description

An ester of testosterone with a propionate substitution at the 17-beta position. [PubChem]

Indication

Testosterone propionate is an anabolic steroid and a short ester form of testosterone that becomes active in the body. It is often used for muscle mass building.

Pharmacology

Toxicity

Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.

Affected Organisms

Humans and other mammals

Biotransformation

Protein Binding

40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins.

Elimination

External Links

• [Drugs.com]

MP Biomedicals

05218655

MP Biomedicals Rare Chemical collection

Sigma Aldrich