CAS 846-50-4|Euipnos|Temazepam|Oxydiazepam|Mabertin|Remestan|Methyloxazepam|Gelthix|N-Methyloxazepam|Planum|Signopam|Restoril|Hydroxydiazepam|Levanxol|Euhypnos|Apo-Temazepam|Novo-Temazepam|Levanzene...

基本信息

化学结构

分子式

C₁₆H₁₃ClN₂O₂

分子量

300.73962

精确质量

300.06655535

电荷

InChI

InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3

InChIKey

SEQDDYPDSLOBDC-UHFFFAOYSA-N

Canonic Smiles

Clc1ccc2c(c1)C(=NC(C(=O)N2C)O)c1ccccc1

Isomeric Smiles

Clc1cc2c(N(C(=O)C(O)N=C2c2ccccc2)C)cc1

计算属性

JChem

Acid pKa

10.676493

质子受体

质子供体

LogD (pH = 5.5)

2.787344

LogD (pH = 7.4)

2.7871175

Log P

2.7873468

摩尔折射率

81.0103

极化性

30.94966

极化表面积

52.9

可自由旋转的化学键

里宾斯基五规则

true

ALOGPS 2.1

Log P

2.16

LOG S

-3.75

溶解度

5.34e-02 g/l

数据来源

学术数据

产品目录

数据来源

名称和标识

商标名

MabertinEuipnosGelthixRemestanNovo-TemazepamLevanzeneCrisonarLevanxolRestorilEuhypnosPerdormCerepaxLevanxeneApo-TemazepamSignopamNormisonTemazPlanum

别名

MethyloxazepamTemazepamOxydiazepamN-MethyloxazepamHydroxydiazepamRestorilER 115Ro 5-5354Planum7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-oneNSC 246303(+/-)-TemazepamNormisonPerdormRemestan3-HydroxydiazepamTemazepam羟基安定

IUPAC传统名

temazepam

IUPAC标准名

7-chloro-3-hydroxy-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

名称和标识

数据登录号

CAS号

846-50-4

PubChem CID

5391

PubChem SID

4650660416096357924900518

CHEMBL

ATC码

美国药典/FDA物质标识码

KEGG ID

DrugBank ID

Medline Plus

维基百科标题

Chemspider ID

EC号

MDL号

数据登录号

化合物性质

产品相关信息

Empirical Formula (Hill Notation)

C16H13ClN2O2

级别

analytical standard

质检报告

下载链接

化合物性质

分子相关蛋白质

暂无数据

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分子图谱

暂无数据

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描述信息

DrugBank

DB00231

Drug Groups

approved

Description

A benzodiazepine that acts as a gamma-aminobutyric acid modulator and anti-anxiety agent. [PubChem]

Indication

For the short-term treatment of insomnia (generally 7-10 days).

Pharmacology

Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action.

Affected Organisms

Humans and other mammals

Biotransformation

Hepatic. Temazepam is completely metabolized through conjugation prior to excretion. The major metabolite is the O-conjugate of temazepam (90%).

Absorption

Well absorbed, minimal first-pass metabolism.

Half Life

10-20 hours

Protein Binding

96%

Elimination

Temazepam was completely metabolized through conjugation prior to excretion; 80% to 90% of the dose appeared in the urine.

References

• Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. [Pubmed]

• Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. [Pubmed]

• Vozeh S: [Pharmacokinetic of benzodiazepines in old age] Schweiz Med Wochenschr. 1981 Nov 21;111(47):1789-93. [Pubmed]

• Shats V, Kozacov S: [Falls in the geriatric department: responsibility of the care-giver and the hospital] Harefuah. 1995 Jun 1;128(11):690-3, 743. [Pubmed]

• Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9. [Pubmed]

External Links

• [Wikipedia]

• [RxList]

• [PDRhealth]

• [Drugs.com]

Wikipedia

Temazepam

Sigma Aldrich

T8275

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
催眠药

TRC

T017200

Pharmacologically active metabolite of Diazepam.Controlled substance (depressant). Sedative, hypnotic.

描述信息

参考文献

PubChem文献

数据源提供

• Shats V, Kozacov S: [Falls in the geriatric department: responsibility of the care-giver and the hospital] Harefuah. 1995 Jun 1;128(11):690-3, 743. Pubmed

• Vozeh S: [Pharmacokinetic of benzodiazepines in old age] Schweiz Med Wochenschr. 1981 Nov 21;111(47):1789-93. Pubmed

• Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. Pubmed

• Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. Pubmed

• Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9. Pubmed

• Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1972)

• Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1972)

• Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972)

• Heel, R.C., et al.: Drugs, 21, 321 (1972)

参考文献

生物活性

PubChem BioAssay

生物活性

数据来源

学术数据

产品目录

名称和标识

商标名

MabertinEuipnosGelthixRemestanNovo-TemazepamLevanzeneCrisonarLevanxolRestorilEuhypnosPerdormCerepaxLevanxeneApo-TemazepamSignopamNormisonTemazPlanum

别名

IUPAC传统名

temazepam

IUPAC标准名

7-chloro-3-hydroxy-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

数据登录号

CAS号

846-50-4

PubChem CID

5391

PubChem SID

4650660416096357924900518

CHEMBL

ATC码

美国药典/FDA物质标识码

KEGG ID

DrugBank ID

Medline Plus

维基百科标题

Chemspider ID

EC号

MDL号

描述信息

DB00231

Drug Groups

approved

Description

A benzodiazepine that acts as a gamma-aminobutyric acid modulator and anti-anxiety agent. [PubChem]

Indication

For the short-term treatment of insomnia (generally 7-10 days).

Pharmacology

Affected Organisms

Humans and other mammals

Biotransformation

Hepatic. Temazepam is completely metabolized through conjugation prior to excretion. The major metabolite is the O-conjugate of temazepam (90%).

Absorption

Well absorbed, minimal first-pass metabolism.

Half Life

10-20 hours

Protein Binding

96%

Elimination

Temazepam was completely metabolized through conjugation prior to excretion; 80% to 90% of the dose appeared in the urine.

References

• Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. [Pubmed]

• Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. [Pubmed]

• Vozeh S: [Pharmacokinetic of benzodiazepines in old age] Schweiz Med Wochenschr. 1981 Nov 21;111(47):1789-93. [Pubmed]

• Shats V, Kozacov S: [Falls in the geriatric department: responsibility of the care-giver and the hospital] Harefuah. 1995 Jun 1;128(11):690-3, 743. [Pubmed]

• Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9. [Pubmed]

External Links

• [Wikipedia]

• [RxList]

• [PDRhealth]

• [Drugs.com]

Wikipedia

Temazepam

Sigma Aldrich

T8275

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
催眠药

TRC

T017200

Pharmacologically active metabolite of Diazepam.Controlled substance (depressant). Sedative, hypnotic.

参考文献

PubChem文献

数据源提供

• Shats V, Kozacov S: [Falls in the geriatric department: responsibility of the care-giver and the hospital] Harefuah. 1995 Jun 1;128(11):690-3, 743. Pubmed

• Vozeh S: [Pharmacokinetic of benzodiazepines in old age] Schweiz Med Wochenschr. 1981 Nov 21;111(47):1789-93. Pubmed

• Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. Pubmed

• Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. Pubmed

• Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9. Pubmed

• Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1972)

• Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1972)

• Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972)

• Heel, R.C., et al.: Drugs, 21, 321 (1972)

生物活性

PubChem BioAssay

化合物性质

产品相关信息

Empirical Formula (Hill Notation)

C16H13ClN2O2

级别

analytical standard

质检报告

下载链接

化合物信息

ID:116