化合物信息

Drug Groups

approved

Description

Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio. [Wikipedia]

Indication

For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.

Pharmacology

Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi through PDE3 inhibition, produces diuresis, and causes an increase in gastric secretion.

Affected Organisms

Half Life

7-9 hours

Protein Binding

60%

Distribution

* 0.3 to 0.7 L/kg

Clearance

* 0.29 mL/kg/min [postnatal age 3-15 days]
* 0.64 mL/kg/min [postnatal age 25-57 days]
* 1.7 mL/kg/min [?1-4 years]
* 1.6 mL/kg/min [4-12 years]
* 0.9 mL/kg/min [13-15 years]
* 1.4 mL/kg/min [16-17 years]
* 0.65 mL/kg/min [Adults (16-60 years), non-smoking asthmatics]
* 0.41 mL/kg/min [Elderly (>60 years). liver, and renal function]
* 0.33 mL/kg/min [Acute pulmonary edema]
* 0.54 mL/kg/min [COPD->60 years, stable non-smoker >1 year]
* 0.48 mL/kg/min [COPD with cor pulmonale]
* 1.25 mL/kg/min [Cystic fibrosis (14-28 years)]
* 0.31 mL/kg/min [Liver disease -cholestasis]
* 0.35 mL/kg/min [cirrhosis]
* 0.65 mL/kg/min [acute hepatitis]
* 0.47 mL/kg/min [Sepsis with multi-organ failure]
* 0.38 mL/kg/min [hypothyroid]
* 0.8 mL/kg/min [hyperthyroid]

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