物质信息
ID:996
名称和标识
别名
Carbamide phenylacetatePhenacetylureaPhenylacetylureaPhenacetylcarbamidePhenacemidePAPhenylacetyluree
商标名
NeophenalPhenaronePhenuronFenisedPhenutalAcetylureumCetylureumComitiadoneFenacemidFenacetamideFenilepNeophedanPhenacereumPhenaceturPhenuroneFenacetil-KarbamideFenostenylFenuralFenureaFenylacetylmocovinaFenytanEfronEpiclaseFelureaFenacemidePhenacalumPhenicarbPhenyritPhetylureumCarbanmideEferonEpheronFenuronePhacetur
IUPAC标准名
(2-phenylacetyl)urea
IUPAC传统名
phenacemide
化合物性质
理化性质
溶解度
10.2 g/L
疏水性(logP)
0.8
描述信息
Drug Groups
approved
Description
Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.
Indication
Used to control certain seizures in the treatment of epilepsy.
Pharmacology
Phenacemide is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures, refractory to other anticonvulsants. Phenacemide elevates the threshold for minimal electroshock convulsions and abolishes the tonic phase of maximal electroshock seizures. It also prevents or modifies seizures induced by pentylenetetrazol or other convulsants.
Toxicity
Oral, mouse: LD50 = 987 mg/kg; Oral, rabbit: LD50 = 2500 mg/kg; Oral, rat: LD50 = 1600 mg/kg
Affected Organisms
Humans and other mammals
Biotransformation
Metabolized in the liver by hepatic microsomal enzymes, where it is inactivated by p-hydroxylation.
Absorption
Almost completely absorbed.
Half Life
22-25 hours.
References
•
Coker SB: The use of phenacemide for intractable partial complex epilepsy in children. Pediatr Neurol. 1986 Jul-Aug;2(4):230-2.
[Pubmed]
•
Coker SB, Holmes EW, Egel RT: Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations. Neurology. 1987 Dec;37(12):1861-6.
[Pubmed]
External Links
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参考文献
• Coker SB: The use of phenacemide for intractable partial complex epilepsy in children. Pediatr Neurol. 1986 Jul-Aug;2(4):230-2. Pubmed
• Coker SB, Holmes EW, Egel RT: Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations. Neurology. 1987 Dec;37(12):1861-6. Pubmed