物质信息

ID:820

名称和标识
别名
Cycrimine hydrochlorideCycrimine
IUPAC标准名
1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
IUPAC传统名
cycrimine
商标名
Pagitane
数据登录号
PubChem CID
PubChem SID
CAS号
化合物性质
理化性质
疏水性(logP)
4
描述信息
Drug Groups
approved
Description
Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.
Indication
For treatment and management of Parkinson's disease.
Pharmacology
Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.
Affected Organisms
Humans and other mammals
Protein Binding
14-21%
References
• Vedasiromoni JR, Ganguly DK: Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. [Pubmed]
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参考文献
• Vedasiromoni JR, Ganguly DK: Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. Pubmed