物质信息

ID:74181

名称和标识
IUPAC标准名
4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
别名
DL-Adrenaline
IUPAC传统名
(+-)-adrenaline
数据登录号
CAS号
化合物性质
安全信息
保存条件
-20°C
产品相关信息
成盐信息
Free Base
药理学性质
作用靶点
GPCR
描述信息
Biological Activity:
DL-Adrenaline is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands. In medicine DL-Adrenaline is used chiefly as a stimulant in cardiac arrest, as a vasoconstrictor in shock, and as a bronchodilator and antispasmodic in bronchial asthma. DL-Adrenaline is found in small amounts in the body and is essential for maintaining cardiovascular homeostasis because of its ability to divert blood to tissues under stress. DL-Adrenaline acts by binding to a variety of adrenergic receptors. DL-Adrenaline is a nonselective agonist of all adrenergic receptors, including α1, α2, β1, β2, and β3 receptors. Epinephrine’s binding to these receptors triggers a number of metabolic changes. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis in muscle. [1][2]References on DL-Adrenaline[1] http://en.wikipedia.org/wiki/Epinephrine, , [2] Am J Physiol. , 1982 Apr, 242(4):H593-601
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参考文献
• Berecek KH et al. Am J Physiol. 1982 Apr;242(4):H593-601.