Research Area: Immunology
Biological Activity:
Phenformin hydrochloride is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. Phenformin is a biguanide. Phenformin can increase AMPK activity without increasing AMP/ATP. In a study, in hearts treated with phenformin for 18 min and then perfused for 20 min with Krebs-Henseleit buffer, [AMP] began to increase at 26 min and AMPK activity was elevated at 36 min. In hearts treated with metformin, [AMP] was increased at 50 min and AMPK activity, phosphorylated AMPK, and phosphorylated acetyl-CoA carboxylase were elevated at 61 min. Phenformin increase AMPK activity and phosphorylation in the isolated heart. The increase in AMPK activity was always preceded by and correlated with increased cytosolic [AMP]. [1][2]References on Phenformin HCl[1] Can Fam Physician., 1968 Feb., 14(2):45-7.[2] http://en.wikipedia.org/wiki/Phenformin, ,