物质信息
ID:737937
名称和标识
IUPAC传统名
pyridine hydrofluoride
IUPAC标准名
pyridine hydrofluoride
别名
Olah's ReagentHydrogen fluoride pyridine complex氟化氢吡啶络合物Pyridinium poly(hydrogen fluoride)
化合物性质
理化性质
密度
1.100
沸点
50°C/1mm
安全信息
联合国危险货物等级
8
联合国危险货物编号
UN1790
GHS危险声明
H300-H310-H330-H314-H318
危险公开号
26/27/28-35
GHS危险品标识
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
急性毒性（口服，皮肤接触，吸入），类别1,2,3
安全公开号
26-28-36/37/39-45
保存注意事项
Moisture Sensitive
TSCA收录
否
欧盟危险性物质标志
剧毒 (T+)GHS警示性声明
P260-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501A
联合国危险货物包装类别(PG)
I
产品相关信息
纯度
ca 70% HF
描述信息
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分子图谱
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参考文献
• For use in electrophilic electrochemical fluorination, see: J. Fluorine Chem., 83, 31 (1997).
• Convenient form of anhydrous HF, showing increased reactivity in many reactions: J. Org. Chem., 44, 3872 (1979). Alkenes and alkynes undergo hydrofluorination; in the presence of NIS or NBS, iodo- or bromofluorination occurs: Synthesis, 779 (1973). Secondary and tertiary alcohols are converted to alkyl fluorides: Synthesis, 653 (1974). Diazotization of ɑ-amino acids in the presence of the reagent provides good yields of ɑ-fluoro acids: Synthesis, 654 (1974). Reaction with aryldiazonium salts or triazenes leads to aryl fluorides, providing a convenient alternative to the Balz-Schiemann reaction (see Tetrafluoroboric acid, L14037): J. Am. Chem. Soc., 97, 208 (1975); J. Chem. Soc., Chem. Commun., 914 (1979); Bull. Chem. Soc. Jpn., 63, 2058 (1990).
• In combination with nitrosonium tetrafluorborate, ketoximes are converted to gem-difluorides: Synlett, 425 (1994).
• The reagent is also widely applied to the cleavage of a variety of silyl protecting groups including TBDMS, TES, TBDPS and TIPS: Synthesis, 453 (1986); J. Am .Chem. Soc., 112, 7001 (1990); for further discussion see: P. Kocienski, Protecting Groups, Thieme, Stuttgart (1994).