物质信息
ID:73437
名称和标识
IUPAC标准名
5-(1,4-diazepane-1-sulfonyl)isoquinoline hydrochloride
别名
Fasudil HClHA-1077
IUPAC传统名
fasudil hydrochloride
数据登录号
CAS号
化合物性质
产品相关信息
成盐信息
hydrochloride
安全信息
保存条件
-20°C
药理学性质
作用靶点
ROCK
描述信息
Research Area: Cancer
Biological Activity:
Fasudil HCl is cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor with an IC50 of 10.7 μM. It is also a Ca2+ antagonist and vasodilator. It also inhibits proliferation of vascular smooth muscle cells. [1]References on Fasudil HCl (HA-1077)[1] Acta Neurochir Suppl., 2001, 77:201-4.
Biological Activity:
Fasudil HCl is cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor with an IC50 of 10.7 μM. It is also a Ca2+ antagonist and vasodilator. It also inhibits proliferation of vascular smooth muscle cells. [1]References on Fasudil HCl (HA-1077)[1] Acta Neurochir Suppl., 2001, 77:201-4.
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参考文献
• Shibuya M et al. Acta Neurochir Suppl. 2001;77:201