Research Area: Solid tumours
Biological Activity:
Docetaxel (Taxotere) is a semi-synthetic, second-generation taxane, with anti-neoplastic application for the treatment of breast, ovarian, and non-small cell lung cancer. [1]Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. The overall cells mean IC50 for docetaxel treatment was 4.67 nM，similar to IC50 values observed across the NCI60 panel of human tumor cell lines, which exhibit a mean docetaxel IC50 of 23.4 nM, with a range of 0.31–100 nM. [2]This agent also inhibits pro-angiogenic factors such as VEGF and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. [3]