物质信息
ID:718761
名称和标识
IUPAC传统名
chlorotriisopropylsilane
IUPAC标准名
chlorotris(propan-2-yl)silane
别名
TriisopropylchlorosilaneTIPSCl三异丙基氯硅烷Chlorotriisopropylsilane
化合物性质
安全信息
欧盟危险性物质标志
腐蚀性 (C)TSCA收录
否
联合国危险货物编号
UN2987
危险公开号
34
保存注意事项
Moisture Sensitive
联合国危险货物包装类别(PG)
II
GHS危险声明
H314-H318-H227
GHS警示性声明
P210-P260-P303+P361+P353-P305+P351+P338-P405-P501A
联合国危险货物等级
8
安全公开号
26-36/37/39-45
GHS危险品标识
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
理化性质
闪点
62°C(144°F)
密度
0.908
沸点
200°C
折射率
1.4535
产品相关信息
纯度
97+%
描述信息
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分子图谱
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参考文献
• Reagent for the protection of alcohols as triisopropylsilyl (TIPS) ethers. See Appendix 4. Methods of introduction include imidazole in DMF: Tetrahedron Lett., 2865 (1974), or imidazole/DMAP: Chem. Lett., 41 (1987). Also useful for N-protection. The steric bulk of TIPS makes it useful as a regio- and stereodirecting group, allowing selective protection of primary hydroxyl in the presence of secondary: Tetrahedron Lett., 2865 (1974). TIPS ethers are more resistant to acidic hydrolysis than TBDMS ethers, but less so than tert-butyldiphenylsilyl (TBDPS) ethers. However, they are more resistant to basic hydrolysis than either TBDMS or TBDPS derivatives: J. Org. Chem., 45, 4797 (1980); 49, 3239 (1984); Tetrahedron Lett., 24, 3455 (1983).
• Cleavage is usually accomplished by treatment with F-: J. Org. Chem., 51, 4941 (1986); see Tetra-n-butylammonium fluoride, A10588. Alternative methods include dilute HCl: Tetrahedron Lett., 2865 (1974), or 80% AcOH: J. Carbohydr., Nucleosides, Nucleotides, 3, 197 (1976).
• For a comprehensive review of the TIPS group in organic chemistry, see: Chem. Rev., 95, 1009 (1995). See also Triisopropylsilyl trifluoromethanesulfonate, B21127.