物质信息
ID:717708
名称和标识
别名
Hydroxylammonium chlorideHydroxylamine hydrochloride盐酸羟胺
IUPAC标准名
hydroxylamine hydrochloride
IUPAC传统名
primary amine hydrochloride
化合物性质
安全信息
GHS危险品标识
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
对水环境的危害
急性危害，类别1
慢性危害，类别1,2
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
不稳定的炸药
不稳定的炸药
不稳定的炸药
有机过氧化物，类别A、B
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
RTECS编号
NC3675000
联合国危险货物包装类别(PG)
III
联合国危险货物等级
8
GHS危险声明
H200-H351-H373-H290-H315-H319-H400-H302-H312-H317
欧盟危险性物质标志
环境危害性 (N)
爆炸性 (E)
有害性 (X)保存注意事项
Hygroscopic
GHS警示性声明
P280H-P273-P406
安全公开号
36/37-61
TSCA收录
是
危险公开号
2-21/22-36/38-40-43-48/22-50
联合国危险货物编号
UN2923
理化性质
熔点
152°C dec.
密度
1.67
产品相关信息
纯度
99%
描述信息
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分子图谱
暂无数据
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参考文献
• For examples of preparation of oximes from carbonyl compounds, see: Org. Synth. Coll., 2, 70, 313 (1955); 7, 149 (1990). Dehydration of aldoximes is a valuable route to nitriles. The preparation of an oxime, and dehydration with acetic anhydride, are exemplified for veratraldehyde: Org. Synth. Coll., 2, 622 (1943). For other methods of dehydrating oximes to nitriles, see Benzaldoxime, A12053. Procedures for the one-pot conversion of aldehydes to nitriles, without isolation of the intermediate oxime, include: refluxing the aldehyde with hydroxylamine hydrochloride in formic acid/ sodium acetate: J. Chem. Soc., 1564 (1965); formic acid alone: Synthesis, 112 (1979); in pyridine and toluene, with azeotropic water removal: Synthesis, 190 (1982); in DMF (reflux; aromatics only): Z. Chem., 15, 302 (1975); heating in NMP at 110-115o, effective for aromatic and aliphatic substrates; under these conditions, DMF gave only 20-30% conversion: Synthesis, 586 (1999). A more recent ambient temperature one-pot procedure utilizes DBU in combination with ethyl dichlorophosphate: Synlett, 1317 (2007).
• For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1326 (2007).
• For a one-pot synthesis of pyrazoles from aldehydes by cyclization of the intermediate oxime in acidic medium with potassium dihyrogen phosphate, see: Tetrahedron Lett., 47, 43 (2006).