物质信息
ID:717042
名称和标识
IUPAC标准名
1H-indole
IUPAC传统名
indole
别名
Indole吲哚
化合物性质
安全信息
联合国危险货物等级
6.1
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
腐蚀金属，类别1
腐蚀皮肤，类别1A，1B，1C
严重眼损伤，类别1
对水环境的危害
急性危害，类别1
慢性危害，类别1,2
危险公开号
21/22-41-50
欧盟危险性物质标志
环境危害性 (N)
有害性 (X)RTECS编号
NL2450000
联合国危险货物包装类别(PG)
III
安全公开号
26-36/37/39-57-60
GHS危险声明
H311-H302-H318-H400
保存注意事项
Light Sensitive
TSCA收录
是
联合国危险货物编号
UN2811
GHS警示性声明
P280-P305+P351+P338-P361-P302+P352-P405-P501A
理化性质
闪点
121°C(249°F)
熔点
50-54°C
密度
1.220
沸点
253-254°C
产品相关信息
纯度
99%
描述信息
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分子图谱
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参考文献
• Treatment of the carbamate with Tri-n-butyltin chloride, A10746, followed by Stille coupling enables synthesis of 2-aryl- and 2-vinylindoles: J. Org. Chem., 60, 6218 (1995).
• Treatment with EtMgI followed by ZnCl2 leads to an N-zinc derivative. This undergoes acylation at the 3-position: Tetrahedron, 46, 6061 (1990).
• Regioselective synthesis of 3-substituted indoles has been described using a sequence of N-silylation, 3-bromination of the 1-TBDMS detivative with NBS, 3-lithiation, treatment with an electrophile to introduce the 3-substituent, and desilylation with TBAF. Good overall yields are obtained for a range of electrophiles: J. Org. Chem., 59, 10 (1994); Org. Synth. Coll., 9, 417 (1998).
• Lithiation of N-protected indoles usually occurs at the 2-position, e.g. benzenesulfonation of the 1-lithio derivative, 2-lithiation with LDA and treatment with pyridine-3,4-dicarboxylic anhydride. This sequence has been reported in a synthetic route to ellipticene and olivacine: J. Org. Chem., 57, 5891 (1992).
• Halogenation in the 2-position has been effected via the Li 1-carbamate and subsequent 2-lithiation: J. Org. Chem., 57, 2495 (1992):
